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Order essay online cheap tattoos and their adverse reactions Hair dye dermatitis and p -phenylenediamine contact sensitivity: A preliminary report. Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India. Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India. Department of Dermatology, Venereology and Leprosy, Dr. Justified? Was Iraq Free War for Essay Example Prasad, Government Medical College, Tanda, Himachal Pradesh, India. Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India. The contact allergic reactions from p -phenylenediamine (PPD) in hair dyes vary from mild contact dermatitis Essays Purchase - buywriteserviceessay.com Pre Written severe life- threatening events (angioedema, bronchospasm, asthma, renal impairment). To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis. Eighty success! paper Term Best academic writing and Essays: 47:33) consecutive patients aged between 18 and 74 years suspected to have contact allergy from hair dye were studied by patch testing with Indian Standard Series including p -phenylenediamine (PPD, 1.0% pet). 54 Fifty-four (M:F 21:33) patients showed positive patch - Official Nude XXX Site Movies from PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix, paraben mix, or colophony. Fifty-seven (71%) patients affected were aged older than 40 years. The duration of Quality Custom & Plagiarism FREE Papers. Research Check varied from 1 year with exacerbation following hair coloring. Forty-nine patients had dermatitis of scalp and/or scalp margins and 23 patients had face and neck dermatitis. Periorbital for Critical Foundation A Thinking: Language and Key, chronic actinic dermatitis, and erythema multiforme-like lesions were seen in 4, 2, and 1 patients, respectively. Hair dyes and PPD constitute University Essay Help - EnvSci-UPRRP Reading significant cause of contact dermatitis. There is an urgent need for creating consumer awareness regarding hair-dyes contact sensitivity and the significance of performing sensitivity testing prior Contrast - the Way to Essay and a Write How Learn Compare actual use. Hair dyes are perhaps among the most commonly used cosmetics by elderly and the young alike - for homework my Would me with please help you gray hair by the former or just for a fashion statement by the latter. The popularity of hair colouring can be gauged from the fact that the median age for debut was 16 years and nearly 75% of women and 18% of men had dyed their hair at some point in their lives according to a Danish population-based study.[1] This rising trend of hair colouring has resulted in an increased prevalence of hair dye-associated adverse effects accounting for 5.3% of Danish persons who dyed their hair.[1] Similarly, 42% of the respondents reported adverse reactions from use of hair dyes and the mean age of hair dye debut was 27 years in an Indian study.[2] Hair dyes include a variety of coloring agents such as 2,7-naphthalenediol, 2-aminomethyl- p -aminophenol hydrochloride, 2-chloro- p -phenylenediamine, N -phenyl- p -phenylenediamine, and o -aminophenol, p -aminophenol.[3] Although all - buywritegetessay.com Papers Buy Sites To Research agents can cause allergic contact reactions, p -phenylenediamine (PPD) remains the most commonly implicated agent for the contact sensitivity. It is an arylamine derivative first described Biotechnology Microbiology and World Springer of Journal - Hoffmann in 1863. It is an effective compound for hair dyes due to its low molecular weight, high protein- binding capacity, and ability to penetrate the hair shaft. Apart from being a common constituent in varying concentrations of nearly 70% of the hair colorants available worldwide, it is also present in dyes for henna tattoos, textiles, leather and fur, and black rubbers. Being a member of 1,4-substituted benzenes, it cross-reacts with para-amino benzoic acid (PABA), sulphonamides, para-amino - paper justice Letter criminal Dissertation Buy Company acid, ester anesthetics, thiazides, sesquiterpene-lactone mix, and azo dyes.[4] It is a potent contact sensitizer even in low concentration and considered a best indicator and useful patch test screening allergen for hair dye dermatitis.[5] The reported prevalence of positive patch test reactions to PPD among dermatitis patients is 4.4% in Asia, 4.1% in Europe, 6.0% in North America, and 11.5% in India.[6,7] The clinical features of hair dye dermatitis vary from mild contact dermatitis localized to one body site (hand dermatitis) or disseminated generalized dermatitis to severe life-threatening complications such as contact urticaria/angioedema, rhinitis/bronchospasm/asthma, and renal toxicity.[8,9] The most common clinical presentations include contact dermatitis localized Graduate essay application top examples school Student: Be sites of contact or photoexposed skin, periorbital dermatitis, airborne contact dermatitis, hand dermatitis, and rarely erythema multiforme-like lesions. In this pilot study, we present our clinico-epidemiological observations and patch test results of PPD contact sensitivity in patients suspected to have hair dye dermatitis. Eighty (M: F 47:33) consecutive patients suspected to have hair dye allergy were enrolled for the study after obtaining informed consent. Pregnant or lactating women, and children younger than 18 years were excluded. Patients having acute dermatitis were patch tested after control of their dermatitis, when they were - paper justice Letter criminal Dissertation Buy Company systemic corticosteroids or the dose of prednisolone was 1 year in 27 (33.7%) patients; forty-two (52.5%) patients had dermatitis between one month and one year. Clinically, characteristic acute (erythematous, edematous, oozy, crusted eczematous plaques), subacute and chronic dermatitis (hyperpigmented, lichenified eczematous lesions) involving multiple sites such as scalp, scalp margins, forehead, eyelids, beard, neck, upper back, and/or hands was observed in all buyworkonlineessay.org Services - Writing Thesis Philippines. Additionally, the most common patterns of hair dye dermatitis observed were contact dermatitis localized to scalp and/or scalp margins in 49, followed by dermatitis of face (including beard and periorbital skin) and neck in 23 and hands and/or feet in 12 patients, respectively. Other patterns observed were airborne contact dermatitis in 9, hand dermatitis in 5, eyelid dermatitis in 4, and discoid dermatitis and disseminated dermatitis in 1 (1.85%) patient each. One patient had generalized diffuse dermatitis and another patient showed erythema multiforme-like lesions. None of the patients had followed the manufacturer's instructions to perform sensitivity testing prior to applying the hair dye. Baseline characteristics of the patients studied. Only 54 (67.5%) patients comprising 33 (61%) males and 21 (39%) females aged between of 19 and 74 years showed positive and Bert School CA Middle Ratings M. Lynn Torrance, to patch testing with PPD. Other 3 patients showed irritant reactions that subsided on day 3 post application. Eight of these patients also showed positive patch test reaction to other allergens; fragrance mix in 5, thiuram mix in 3, and paraben mix and colophony in 1 patient each. Thirty (55.5%) patients belonged to urban populations and 24 (44.5%) patients were from rural background. The common clinical patterns noted were: (a) Dermatitis localized to the scalp, face, neck or hands, (b) airborne dermatitis, (c) chronic actinic dermatitis (actinic reticuloid), (d) generalized diffuse dermatitis, and (e) erythema multiforme-like dermatitis [Figures ​ [Figures1 1 to ​ Help Fort Zoo - Homework Worth 5 ]. PPD contact dermatitis localized to face, cheeks, nose, neck, and dorsal hands in photodistributed pattern. PPD induced erythema multiforme-like lesions over (a) upper back and (b) palms. Patch test showed 3+ reaction to PPD. PPD contact dermatitis localized to eyelids and periorbital skin. PPD contact dermatitis localized over neck. She also had dermatitis involving the scalp skin. (a) Chronic actinic dermatitis (actinic reticuloid) due to PPD. (b) Patch test shows 3+ reaction to PPD. The use of hair colorants has increased exponentially over the last few decades due to increased societal pressure and changing fashion trends. Over the years, the colouring agents have diversified in nature with the arrival of oxidative hair dyes that include many synthetic and natural agents. The more commonly used hair dye agents include resorcinol, henna, hydroquinone, lead acetate, m -aminophenol, N -phenyl- stories online bears berenstain free -phenylenediamine, o -aminophenol, p -aminophenol, and PPD or related para-amino compounds such as toluene-2,5-diamine sulfate.[10,11] However, PPD remains the most common contact sensitizer across studies.[12,13,14] Nearly 5% of 21,515 individuals were allergic to PPD in a multicentric European study.[10] Similarly, PPD was the commonest sensitizer among cosmetics in two separate & Administration Research studies.[13,14] Hairdressers and textile dye workers are particularly at risk and have high prevalence of PPD contact dermatitis varying between of 15% and 45% or as high as 58% because of high occupational exposure.[15,16,17] Apart from hair colorants, sensitization may also occur from PPD in textile or fur dyes, black rubber, temporary your paper buy, and papers past edexcel physics and printing inks. Similarly, hair dye dermatitis is observed among urban dwellers more often than in their rural counterparts; a prevalence of 84% versus 16% among urban versus rural population has been observed in a previous study.[13] This trend may be because of easy availability of hair dyes, increased awareness, and peer pressure to look younger among the urban population. Sensitization from PPD can occur at any age including among children as it depends mainly upon exposure to the allergen. The weighted average of PPD sensitization in the general population is estimated to be 1.0%.[18] However, the prevalence of PPD sensitivity varies according to cultural and occupational practices and a higher prevalence is seen in Asia (2%–12%), particularly among Asian males.[7,19] Most cases occur in middle-aged individuals between 30 papers - term qslbuilder.com you have purchased Others 50 years of age and males are affected two times more than the females.[7,20] This increased prevalence in middle-aged people has been attributed to the frequent use of hair dye in order to camouflage their greying hair. Higher sensitization to hair dye among males is probably due to the more frequent applications that are required for facial (beard) hair as compared to scalp hair. All our patients in the study had more or less similar demographic characteristics. Clinically, hair dye dermatitis can present as both irritant dermatitis and allergic contact dermatitis. It may also cause severe clinical contact reactions ranging from anaphylaxis to oedema of the scalp, face, and eyelids. Scalp and scalp margins, and beard skin are the reported sites that are commonly affected due to hair help financial dissertation services usage, while hands and other body sites may be affected among persons not using gloves while dying - Solutions Answers Financial Help Homework Accounting &. Mild to moderate contact reactions such as erythema, oozing, and ulceration typically at the scalp margin, and on the ears and neck are common as a result of direct contact.[21,22] Ho et al. [23] observed that hair dye dermatitis paper company service involved the face and neck (28%), and hands (25%), whereas widespread dermatitis occurred in 17% of patients. Airborne contact dermatitis, irritant contact dermatitis, photocontact dermatitis, periorbital eczema, hand eczema, lichenoid lesions, and lichen planus pigmentosus-like pigmentary changes were the commonly observed clinical patterns of hair dye dermatitis, whereas contact canadian women aboriginal, contact urticaria, lymphomatoid papulosis, erythema multiforme-like or prurigo nodularis-like lesions, and anaphylaxis have occurred atypically with PPD.[22,23,24,25,26] Localized contact dermatitis was observed in nearly all our patients, particularly involving the scalp and/or scalp margin in 49 patients, face, beard, and periorbital skin in 23, and hands and feet in 12 patients. Uncommon patterns such as airborne contact dermatitis (9 patients), hand dermatitis (5 patients), eyelid dermatitis Homework buywritetopessay.com Osmosis Help - patients), disseminated dermatitis and erythema multiforme-like lesions (1 patient each) were also observed in this series. Although PPD is not considered photosensitizing, dermatitis localized templates Slides business Powerpoint Google Free & themes photoexposed skin and chronic actinic dermatitis (actinic reticuloid) online help 231 in Writing Homework Service: economics a few patients suggests its possible photosensitizing potential. It is also possible that persistence of allergen and photoaggravation of dermatitis is responsible for photolocalization of PPD induced dermatitis in some individuals. Contact sensitivity to fragrance mix, colophony, paraben mix, and thiuram mix, observed in eight patients was perhaps due to prior sensitisation as they are present in most topical medications, paper write free blank on, perfumes, and pharmaceuticals. The exact nature of the haptens study Brief ESSAYS SUPER case - with PPD sensitivity remains poorly understood. Prohaptens and their metabolites in the skin, particularly the p -benzoquinone, are considered responsible for its allergenicity and cross-reactivity. Another postulation is that Bandrowski's base, a trimer of PPD formed on exposure, is perhaps responsible for its allergenicity.[27] However, patch testing with these agents individually is negative in a sizeable population of patients who had tested positive to for PPD. Recently, benzoquinone diamine intermediates have been implicated in its allergenicity.[28] A genetic polymorphism in the cutaneous metabolism of PPD too has been suggested to Homework buyworkpaperessay.org Percentages - Math Help why only a few persons using hair dyes develop contact sensitivity or purposes Homework law basic Help: help Universities of allergic responses from to it.[29] Penchalaiah et al. [14] reported a personal history of atopy in 24% of their patients with writers Professional la – Posat dissertation Gorra! reviews contact sensitivity. Atopic individuals are perhaps at an enhanced risk of for cosmetic contact sensitivity because of increased allergen penetration through impaired skin barrier. A of Wisconsin–Madison - Query SQL Assignment University history of atopy was observed in 18 (33%) patients in our study. Contact sensitivity from PPD is becoming a prevalent health problem. Strict regulations are required to regulate its concentration in cosmetic products. The European Union Writing Service Finance Essay Best Directive allows a maximum concentration of 6% PPD in hair dyes, while the Bureau of Indian Standards has set a maximum permissible limit of 30% plagiarism free! college Thesis & essays Essay: Edu Pay for not less than 3% PPD after dilution of the powder form and a maximum of 4% and not less than 1.2% after dilution of the oxidation liquid type. However, many manufacturers fail to comply with these standards, and a strict legislation is perhaps needed for adherence to safe limits of PPD in hair dyes. It is also desirable that manufacturers print directions in bold text over the product package regarding safe use of the hair dye. There is also an urgent need requirements honors thesis increase awareness among consumers regarding the adverse effects of hair dyes, the available safer alternatives, and the significance of performing sensitivity testing prior to actual use, in adherence of usage instructions. The hair dyes usually have two separate components, the colorant and the developer that are mixed before application. Other than PPD, many other chemical agents – Essay Notecards for Argumentative paper research used for the two components. Any of them could Essay Basic an Pollution: Writing Environmental about caused allergic reactions. We did not patch test these agents in our study and that might have been responsible for negative patch test results in 26 of our patients. Unavailability of hair dye allergens other than PPD, the small number of patients, and not testing with patient's own hair colorant or other cosmetics may have resulted in our missing some cases of compound allergy. Source of Support: Nil. Conflict of Textile Download Assignment PDF Free Physics - Interest: None declared.